Manufacturing of liquid emulsion (Emulsion: A type of liquid dosage form)

Manufacturing of liquid emulsion (Emulsion: A type of liquid dosage form)


Manufacturing of liquid emulsion For manufacturing of liquid emulsion mechanical energy by agitation is applied for application of the mechanical energy various equipments such as mechanical stirrers propeller mixture turbine mixtures, colloidal mill, homogenizer and ultransonic devices are utilized for application of the mechanical energy and the containers such as stainless steel kettle stainless steel pipes stainless steel tank with the heating and cooling capabilities then solution transfer system and filter press such containers and equipments are utilized for the production of emulsion generally for the preparation of oral emulsion means oral liquid emulsion are generally oil-in-water type of the emulsion Most of the water-in-oil type of emulsion are used for the topical products So here we are not discussing water-in-oil type of emulsion as it is covered in the manufacturing of the semi-solid products here we are discussing only about the liquid emulsion Which are mainly O/W type of emulsion O/W type of emulsion in industry are prepared by phase inversion technique initially primary emulsion is prepared and after the preparation of primary emulsion final emulsion is prepared by addition of the remaining amount of the aqueous phase for the preparation of the primary emulsion various ratio of the oil water and gum is utilized if you are using the fixed oil the ratio of oil/water/gum is 4:2:1 If we are utilizing mineral oil at that time the ratio of primary emulsion is 3:2:1 and if you’re utilizing volatile oil at that time the ration is 2:2:1 we have to calculate the quantity for the primary emulsion after deciding the quantity for primary emulsion first of all we are preparing the mixture of the oil plus gum that is the dry gum method that we are utilizing first of all, oil and gum is mixed and triturated after that the quantity of the water required for the primary emulsion is added at once the water is not added dropwise here it is area at once to the mixture of the oil and gum come and triturated This is the primary emulsion after the primary emulsion is prepared the remaining amount of the aqueous phase is added to the primary emulsion and the final volume is made here, for the preparation of the emulsion before starting the method of preparation the oil soluble components are mixed into the only phase and water soluble components are mixed into the aqueous phase here, the aqueous phase is divided in two parts that is the aqueous phase for the primary emulsion an aqueous phase to prepare final emulsion so the water soluble components are dissolved into the final emulsion into the quantity of the water required to prepare finally emulsion water soluble components are not added into the quantity which is required to to prepare primary emulsion because the soluble components interfere with the preparation of the emulsion the water-soluble components are added into the quantity of the water which is required to prepare final emulsion that is after preparation of the primary emulsion in case of the oil soluble component all the oil soluble components are dissolved into the the oily phase and this oil is utilized for the preparation of primary emulsion In case of the wet gum method, we mix gum plus water first of all we mix gum and water to prepare a mucilage in this mixture, oil is added dropwise here, we are not adding oil at once, but oil is added dropwise with trituration to prepare primary emulsion after the preparation of primary emulsion remaining amount of aqueous phase is added gradually with trituration to make up the volume try to answer to make up the final so this was about the wet gum method

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